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Potential for nutrient absorption issues (related to persistent GI side effects) Persistent gastrointestinal side effects of Rybelsus, especially vomiting and diarrhea, can cause nutritional deficiencies

The expression of pivotal lipolytic enzymes, Pnpla2 (encoding ATGL) and Lipe (encoding HSL), was reduced by approximately 73% and 58%, respectively

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Secondary deficiency is a different animal

In the light of a recent cohort study by Tang and his colleagues, comprising 4,000 individuals for 3 years, it has been found that TMAO can be a new biomarker for cardiac mortality, MI, or cerebrovascular accidents in addition to increasing cardiac-related mortality by 2.5 times [73, 74]